Revolutionizing human medicine with molecular glues

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Magnet Biomedicine’s modular TrueGlue™ technology enables the systematic discovery of molecular glues towards the treatment of human disease.

Our technology builds upon the discoveries of our Scientific Founders, who provided the seminal observations on molecular glues and have explored them for over 30 years.

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THE SCIENCE

TrueGlues are compounds that induce cooperative interactions between multiple proteins

Targeted protein degradation has revealed the potential of molecular glues to treat human disease. Historically, TrueGlues have been found by chance; Magnet Biomedicine is changing that. The Magnet team is leveraging human genetics and proteomic data to select protein pairs for the development of monovalent molecular glues, altering the function of targets by degradation, stabilization, or inhibition. Magnet will pioneer the discovery of novel molecular glue medicines for the treatment of cancer, cardiovascular disease, and immune disorders. Rationally designed molecular glues will restrict drug effects to disease-relevant tissues, induce biological synergy, and target undruggable proteins.

OUR TECHNOLOGY

Building upon recent advances in proteomics, screening, and bioinformatics, we believe the time is now to execute on this long-standing goal of rational molecular glue discovery

Our TrueGlue discovery platform combines state-of-the-art screening technologies utilizing diverse chemical libraries and human-biology-driven target selection. Our process integrates diverse streams of in-house and external data to discover and exploit novel molecular glue mechanisms of action.  Magnet’s TrueGlue technology can be applied in an indication-agnostic manner to discover molecular glues with a wide range of target modulation, drug-like properties, and selectivity.  

OUR PEOPLE

Brian Safina
Brian Safina, Ph.D.
President & Chief Scientific Officer
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Bret Williams
Bret Williams, Ph.D.
Vice President of Biology
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Matthew Hayward
Matthew Hayward, Ph.D.
Vice President of Drug Discovery
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Jennifer Franklin
Jennifer Franklin
Vice President of Administration & Operations
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Kristina Burow
Kristina Burow
Managing Director at ARCH Venture Partners
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Thomas Cahill
Thomas Cahill, M.D., Ph.D.
Founder and Managing Partner at Newpath Partners
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Ramnik Xavier, M.D., Ph.D.
Scientific Advisory Board Chair
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Benjamin F. Cravatt, Ph.D.
Founder & Advisor
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David Spiegel
David A. Spiegel, M.D., Ph.D.
Founder & Advisor
Michael Rosbash
Michael Rosbash, Ph.D.
Founder & Advisor
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Richa Saxena, Ph.D.
Founder & Advisor
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Stuart Schreiber, Ph.D.
Founder & Advisor
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Xiao Chen
Xiao Chen, Ph.D.
Biology
YiQun Chen
YiQun Chen
Biology
Jessica Gasser
Jessica Gasser, Ph.D.
Biology
Shubhroz Gill
Shubhroz Gill, Ph.D.
Biology
Bruce Hua
Bruce Hua, Ph.D.
Chemistry
Liam Hudson
Liam Hudson, Ph.D.
Chemistry
Chueh-Ling Kuo
Chueh-Ling Kuo, Ph.D.
Biomolecular Discovery
Igor Levchenko
Igor Levchenko, Ph.D.
Protein Production
Alyssa Lutservitz
Alyssa Lutservitz, MS
Informatics
Ashish Maurya
Ashish Maurya, Ph.D.
Biology
Andrew Reidenbach
Andrew Reidenbach, Ph.D.
Biomolecular Discovery
David Rhee
David Rhee, Ph.D.
Proteomics
Tiffany Tsang
Tiffany Tsang, Ph.D.
Biology
Hsin-Lan Wen, Ph.D.
Biology

OUR INVESTORS

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CAREERS

Magnet Biomedicine is building a world-class team to unleash the scientific breakthroughs and expertise of our Founders.

We are looking for creative, thoughtful, science-first innovators to join our collaborative team. Come help us realize the potential of molecular glues to achieve the broadest possible impact for patients.

Click the job openings to learn more.

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NEWS

The latest Magnet news and presentations

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09.19.2023

Magnet Biomedicine Emerges from Stealth with $50 Million to Advance Rational Approach to Molecular Glues with TrueGlue™ Discovery Platform

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