Revolutionizing human medicine with molecular glues
Magnet Biomedicine’s modular TrueGlue™ technology enables the systematic discovery of molecular glues towards the treatment of human disease.
Our technology builds upon the discoveries of our Scientific Founders, who provided the seminal observations on molecular glues and have explored them for over 30 years.
TrueGlues are compounds that induce cooperative interactions between multiple proteins
Targeted protein degradation has revealed the potential of molecular glues to treat human disease. Historically, TrueGlues have been found by chance; Magnet Biomedicine is changing that. The Magnet team is leveraging human genetics and proteomic data to select protein pairs for the development of monovalent molecular glues, altering the function of targets by degradation, stabilization, or inhibition. Magnet will pioneer the discovery of novel molecular glue medicines for the treatment of cancer, cardiovascular disease, and immune disorders. Rationally designed molecular glues will restrict drug effects to disease-relevant tissues, induce biological synergy, and target undruggable proteins.
Building upon recent advances in proteomics, screening, and bioinformatics, we believe the time is now to execute on this long-standing goal of rational molecular glue discovery
Our TrueGlue discovery platform combines state-of-the-art screening technologies utilizing diverse chemical libraries and human-biology-driven target selection. Our process integrates diverse streams of in-house and external data to discover and exploit novel molecular glue mechanisms of action. Magnet’s TrueGlue technology can be applied in an indication-agnostic manner to discover molecular glues with a wide range of target modulation, drug-like properties, and selectivity.
Brian Safina, Ph.D.President & Chief Scientific Officer
Bret Williams, Ph.D.Vice President of Biology
Matthew Hayward, Ph.D.Vice President of Drug Discovery
Jennifer FranklinVice President of Administration & Operations
Kristina BurowManaging Director at ARCH Venture Partners
Thomas Cahill, M.D., Ph.D.Founder and Managing Partner at Newpath Partners
Benjamin F. Cravatt, Ph.D.Founder
David A. Spiegel, M.D., Ph.D.Founder
Michael Rosbash, Ph.D.Founder
Richa Saxena, Ph.D.Founder
Stuart Schreiber, Ph.D.Founder
Xiao Chen, Ph.D.Biology
Jessica Gasser, Ph.D.Biology
Shubhroz Gill, Ph.D.Biology
Bruce Hua, Ph.D.Chemistry
Liam Hudson, Ph.D.Chemistry
Chueh-Ling Kuo, Ph.D.Biomolecular Discovery
Igor Levchenko, Ph.D.Protein Production
Alyssa Lutservitz, MSInformatics
Ashish Maurya, Ph.D.Biology
Andrew Reidenbach, Ph.D.Biomolecular Discovery
David Rhee, Ph.D.Proteomics
Tiffany Tsang, Ph.D.Biology
Hsin-Lan Wen, Ph.D.Biology
Magnet Biomedicine is building a world-class team to unleash the scientific breakthroughs and expertise of our Founders.
We are looking for creative, thoughtful, science-first innovators to join our collaborative team. Come help us realize the potential of molecular glues to achieve the broadest possible impact for patients.
Click the job openings to learn more.
Founded by Ben Cravatt, Michael Rosbash, Richa Saxena, David Spiegel, and Stuart Schreiber and backed by leading venture capital partners, we are rapidly growing our team and looking for creative, collaborative, and action-oriented individuals to help drive our molecular glue discovery platform.
The Magnet Biomedicine platform integrates innovative screening technologies, human biology driven protein selection, and state-of-the-art proteomics methods to enable the rational discovery of molecular glues.
Scientist/Senior Scientist, Proteomics
We are seeking a scientist with a strong background in experimental and computational proteomics to join our growing team at Magnet Biomedicine. This is an exciting opportunity to contribute to the discovery of molecular glue therapeutics, while helping to push the boundaries of what is possible as we advance our drug discovery proteomics platform.
The ideal candidate will provide expertise in the development, optimization, and analysis of quantitative proteomics experiments, as well as hands-on experience with the maintenance, quality control, and troubleshooting of instrumentation. Interest and experience with the development of proteomics focused computational workflows and integration with other data types is highly desired.
Magnet offers competitive pay and benefits including medical, dental, and vision insurance, incentive plan, 401(k) program, and a generous holiday and PTO policy. This is a full-time position in Cambridge, MA.
- The development and optimization of robust quantitative proteomic workflows.
- Maintenance, quality control, and troubleshooting of instrumentation.
- Identification, evaluation, and implementation of new methods.
- Data management, analysis, and integration with other platform resources.
- Ph.D. in Analytical Chemistry, Biochemistry, Chemical Biology, or a related field with 3+ years of experience in quantitative proteomics.
- Broad experience with proteomics sample preparation.
- Extensive hands-on knowledge of instrument maintenance and QC.
- Experience with quantitative proteomics methods (SRM/PRM, TMT, SILAC, DIA, Label-free)
- Proficiency with search and analysis software (MaxQuant, PD, Fragpipe, Skyline, etc.)
- Proficiency with downstream statistical analysis (Perseus, R, Python, MSstats, etc).
- Experience with protein-protein interaction methods, PTM workflows, chemoproteomics, and thermal proteome profiling is a plus (IP-MS, proximity labeling, XL-MS, TPP/PISA)
- Cell culture experience is a plus.
About the job
Founded by Stuart Schreiber, Michael Rosbash, Ben Cravatt, Richa Saxena, and David Spiegel and backed by leading venture capital partners, we are rapidly growing our team and looking for creative, collaborative, and action-oriented individuals to help drive our molecular glue discovery platform. The Magnet Biomedicine platform integrates innovative screening technologies, human biology driven protein selection, and state-of-the-art proteomics methods to enable the rational discovery of molecular glues.
Scientist/Senior Scientist, Compound Management
We are seeking a scientist with a strong background in compound management and laboratory automation to join our growing team. This is an exciting opportunity to contribute to the discovery of molecular glue therapeutics through building a highly integrated internal compound management and high throughput chemistry platform.
- Lead all compound management functions including inventory of small molecule screening collections and building blocks, biological materials, sample tracking, distribution, and data management.
- Fulfill dry and solution-based compound sample requests for internal and external partners.
- Troubleshoot liquid handling platforms and analytical instrumentation.
- Development of automation systems for solution manipulations.
- Integrate with medicinal chemistry and analytical sciences to ensure optimal program progression and data quality.
- Seven (7) years of relevant post-degree work experience is required with a Bachelor’s degree.
- Five (5) years of relevant post-degree work experience is required with a Master’s degree.
- Three (3) years of relevant post-degree work experience is required with a PhD.
- Considerable experience with internalized compound management of small molecules (Hamilton or Azenta experience preferred).
- Proficiency with use and basic maintenance of analytical equipment, specifically LCMS.
- Proficiency with LIMS integration, compound registration and inventory management software (Dotmatics preferred).
- Familiar with laboratory operations and management.
- Excellent organization and communication skills.
- Must be flexible and responsive to changing priorities.
- Enthusiasm for taking on new projects and grow with a growing company.
- Commitment to maintain the highest standards of safety and compliance.